CD26
DPPIV

Lyophilized. Lyophilized from 2 mM Tris buffer, pH 8.0 AVOID FREEZE/THAW CYCLES. Native DPP-IV purified from human placenta. DPP-IV is a serine exopeptidase dimer composed of two identical subunits of 110-130 kDa. DPP-IV is involved in many cellular processes such as activation of cytokines, differentiation, and cell-matrix interactions. Inhibition of DPP-IV has been reported to be an effective treatment for type II diabetes. MW: ~220000-260000 (unreduced) Specific activity: ≥10 U/mg. One unit is defined as the amount of enzyme that will hydrolyze 1 µmole H-Gly-Pro-pNA per min at room temperature, pH 8.0. Purity: ≥95% by SDS-PAGE. Prepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV-1, HIV-2, HBsAg, and HCV. EC 3.4.14.5. Note: 1 MIU = 1 milliunit.

Ref.: Leiting, B., et al. 2003. Biochem J. 371, 525. Pospisilik, J.A., et al. 2003. Diabetes 52, 741. Marguet, D., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6874. Misumi, Y., et al. 1992. Biochim. Biophys. Acta 1131, 333.