White solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC50 = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation. Purity: ≥95% by HPLC. Ref.: Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81. |
