1-Benzyl-3-cetyl-2-methylimidazolium iodide
CaM-Dependent Kinase III Inhibitor, NH125
1-Cetyl-3-benzyl-2-methylimidazolium iodide Yellow solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent. Purity: ≥95% by HPLC. CAS 278603-08-0. Ref.: Arora, S., et al. 2004. Mol. Pharmacol. 66, 460. Arora, S., et al. 2003. Cancer Res. 63, 6894. Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.
R: 36/37/38; S: 26-36 |
