5-Fluoro-3,4-dihydro-4(3′-hydroxyphenyl)quinazoline-2(1H)-thione

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC₅₀ = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC₅₀ = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells. Purity: ≥99% by HPLC. CAS 909250-29-9.

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