(5R,11aS)-2-Benzyl-5-(3-hydroxyphenyl)-6H-1,2,3,5,11,11a-hexahydro-imidazo[1,5-b]-b-carboline-1,3-dione White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable HR22C16 (Cat. No. 385861) derivative that exhibits much enhanced potency against mitotic kinesin Eg5-ATPase activity (IC50 = 0.65 vs. 4.3 µM for trans-24 and HR22C16, respectively) and little or no activity against 9 other kinesins. Shown to induce monoastral phenotype in HeLa cells (20 µM). Purity: ≥99% by HPLC. CAS 869304-55-2. Ref.: Sunder-Plassmann, N., et al. 2005. Bioorg. Med. Chem. 13, 6094. |
