4,4′,5,5′,6,6′-Hexahydroxydiphenic Acid 2,6,2′,6′-Dilactone Beige solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Purity: ≥96% by HPCE. RTECS DJ2620000, CAS 476-66-4. Merck Index: 14, 3547
Ref.: Cozza, G., et al. 2006. J. Med. Chem. 49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer 23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.
R: 36/37/38; S: 26-36 |
