N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 µM). Does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease. Purity: ≥95% by HPLC. CAS 127373-66-4. Ref.: Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768. Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814. |
