7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid White solid. A cell-permeable, specific inhibitor of protein phosphatase 2A (PP2A, IC50 = 90 nM). Exhibits only a weak effect on PP1 (IC50 = 5 µM). Causes dose- and time-dependent cytostasis at the G2/M phase in hepatocellular carcinoma cell lines. Purity: ≥98% by TLC. RTECS RN7875000, CAS 145-73-3. Ref.: Ayaydin, F., et al. 2000. Plant J. 23, 85. Thiery, J.P., et al. 1999. Hepatology 29, 1406. Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435. Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.
R: 21-25-36/37/38; S: 36/37/39-45 |
