CD10
Common Acute Lymphocytic Antigen
Endopeptidase-24.11
Enkephalinase
Microvillus Proteinase
Neprilysin Lyophilized. Lyophilized from 150 mM NaCl, 25 mM Tris-HCl, 5 mM CaCl2, TRITON® X-100 Detergent, pH 7.4. Native, neutral endopeptidase from porcine kidney. A cell surface, zinc containing metallopeptidase that is abundant in the brush border membrane of the kidney proximal tubules. Also present in brain, endothelial cells, liver, and lung. Peptidase activity is specifically directed toward the cleavage on the amino side of hydrophobic residues. Contains an arginine in the active site that can interact with the C-terminal carboxylate of substrates. Specific activity: ≥850 units/mg protein. One unit of enzyme will liberate 1.0 µmol pNA per min from Glutaryl-(Ala)2-Phe-pNA at 25°C, pH 7.4. Purity: ≥95% by HPLC. EC 3.4.24.11. Ref.: Barnes, K., et al. 1995. J. Neurochem. 64, 1826. Gafford, J.T., et al. 1983. Biochemistry 22, 3265. |
