White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An antitumor and anti-inflammatory agent that acts as a potent, highly specific, and irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidyl-glutamyl peptide hydrolyzing (PGPH) activities of the proteasome. Modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z. Does not affect the activities of non-proteasomal proteases such as trypsin, cathepsin B, or chymotrypsin. Purity: ≥95% by HPLC. Ref.: Meng, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 10403. Sin, N., et al. 1999. Bioorg. Med. Chem. Lett. 9, 2283. Hanada, M., et al. 1992. J. Antibiot. 45, 1746. |
