White solid. Irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant. Purity: Single spot by TLC. RTECS RR0390000, CAS 66701-25-5. Ref.: Matsumoto, K., et al. 1999. Biopolymers 51, 99. Sarin, A., et al. 1994. J. Immunol. 153, 862. Sarin, A., et al. 1993. J. Exp. Med. 178, 1693. Barrett, A.J. 1982. Biochem. J. 201, 189. |
