Sal Beige solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit a (eIF-2a). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. Purity: ≥90% by HPLC. Ref.: Boyce, M., et al. 2005. Science 307, 935. | 
