EpoB Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells). Purity: ≥95% by NMR. Ref.: Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904. Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642. Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534. Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344. Nicolaou, K.C., et al. 1997. Nature 387, 268. Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.
R: 23/24/25-37/38-41-46-60; S: 22-26-36/37/39-45
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