4-Estren-3a,17b-diol White solid. PACKAGED UNDER INERT GAS. A steroid ligand that displays lower binding affinity for the estrogen receptor and has no classical transcriptional activity. Shown to attenuate osteoblast apoptosis, stimulate osteoclast apoptosis, and increase bone mass and strength without affecting reproductive organs in a non-sex-specific mechanism of action. May be useful in studies pertaining to hormone replacement therapy for osteoporosis. Purity: ≥98% by TLC. CAS 35950-87-9. Ref.: Kousteni, S., et al. 2002. Science 298, 843. |
