VP-16 White solid. PROTECT FROM LIGHT. A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells. Purity: >97% by HPLC. RTECS KC0190000, CAS 33419-42-0. Merck Index: 14, 3886
Ref.: De Lange, A.M., et al. 1995. J. Virol. 69, 2082. Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976. Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147. Terada, T., et al. 1993. J. Med. Chem. 36, 1689. Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70. Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451. Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
R: 22-45; S: 26-36/37/39-45 |
