Dark brown solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents b-amyloid peptide (Ab)-induced free radical formation and lipid peroxidation. Imparts protection against Ab40 and Ab42 toxicity in hippocampal cultures. Purity: ≥90% by elemental analysis. Ref.: Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359. Brandier, C., et al. 1997. J. Vasc. Res. 34, 49. Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247. Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312. Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331. Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.
Not available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States. |
