2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester
2-(4-Fluorobenzoylamino)methylbenzoate White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells (IC50 = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and redirecting the traffic back to ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor Brefeldin A (BFA; Cat. No. 203729), its effect seems to be limited to Golgi, as no effect can be detected on endocytic organelles, such as endosomes and TGN (trans-Golgi network). Its inhibitory mechanism and target(s) appear to be quite different from those of BFA and thus serves as a valuable alternative that complements BFA in membrane traffic studies. Purity: ≥95% by HPLC. CAS 75541-83-2. Ref.: Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469. | 
