4-[(E)-2-(Indol-3-yl)ethenyl]-N-methylpyridinium iodide

Orange solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable, fluorogenic, delocalized lipophilic cationic compound that acts as a mitochondrial toxin and possesses the dual ability to induce apoptosis as well as necrosis in tumor cells. Preferentially accumulates in mitochondria, inhibits oxidative phosphorylation and causes mitochondrial transmembrane depolarization. The incorporation and localization of F16 can be easily monitored by its fluorescence property. Purity: ≥97% by HPLC. Excitation max.: ~420 nm, Emission max.: ~520 nm. CAS 36098-33-6.

Ref.: Fantin, V.R., and Leder, P. 2004. Cancer Res. 64, 329. Fantin, V.R., et al. 2002. Cancer Cell 2, 29.