Brown solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC50 = 0.35 µM). It inhibits Cdk6/D1 with much lower potency (IC50 = 3.4 µM) and has been shown not to affect the activities of several other Cdk’s (IC50 > 20 µM) and tyrosine kinases (IC50 > 10 µM). Part of its biological effects may also be attributed to its ability to intercalate into DNA. Has also been shown to display anti-microbial activity. Purity: ≥98% by NMR. Ref.: Hormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917. Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825. Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.
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