a-Cyano-3-phenoxybenzyl-a-(4-chlorophenyl)isovalerate White glassy solid. A synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 2-4 nM). May also have varied effects on ion channels. Induces depolarization by keeping Na+ channels in an open state. Purity: ≥99% by GC. RTECS CY1576350, CAS 51630-58-1. Merck Index: 14, 4010
Ref.: Richter, A., et al. 1995. Biochem Pharmacol. 49, 367. Salgado, V.L., and Narahashi, T. 1993. Mol. Pharmacol. 43, 626. Sarkar, S.N., et al. 1993. Biochim. Biophys. Acta 1147, 137. Enan, E., and Matsumura, F. 1992. Biochem. Pharmacol. 43, 1777. Narahasi, T. 1992. Trends Pharmacol. Sci. 13, 236.
R: 25-36/37/38; S: 26-36/37/39-45 |
