Cathepsin B, Inhibitor I
Z-FA-FMK

Off-white solid. PROTECT FROM MOISTURE. A cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1a and IL-1b. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position. Purity: ≥98% by HPLC. CAS 96922-64-4.

Z-Phe-Ala-FMK

Ref.: Schotte, P., et al. 2001. J. Biol. Chem. 276, 21153. Guo, H., et al. 1998. Exp. Cell Res. 245, 57. Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057. Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201. Rauber, P., et al. 1986. Biochem. J. 239, 633. Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397. Rasnick, D. 1985. Anal. Biochem. 149, 461.
Sold under license of U.S. Patents 5,210,272 and 5,344,939.