White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3. Purity: ≥98% by HPLC. CAS 301305-73-7. Ref.: Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282. |
