LY-110140
dl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl
(±)-N-Methyl-3-phenyl-3-[(a,a,a-trifluoro-p-tolyl)oxy]propylamine, HCl
Prozac

White to off-white crystalline solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca²⁺ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of M_r 32,000) and AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-kB. Purity: ≥98% by HPLC. CAS 59333-67-4.

Merck Index: 14, 4185
Ref.: Bartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507. Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159. Zhang, A., et al. 2002. J. Med. Chem. 45, 1930. Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182. Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.