w-CgTx GVIA Lyophilized. A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors). Purity: ≥98% by HPLC. CAS 106375-28-4. H-Cys1-Lys-Ser-Hyp-Gly-Ser-Ser-Cys8-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys15-Cys16-Arg-Ser-Cys19-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys26-Tyr-NH2 (disulfide bonds: 1 → 16; 8 → 19; 15 → 26) Ref.: Lalo, U.V., et al. 2001. Brain Res. Bull. 54, 507. Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449. Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43. Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067. Protti, D.A., et al. 1991. Brain Res. 557, 336. Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742. Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337. Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
R: 26/27/28; S: 45-36/37/39
Not available for sale outside of the United States. |
