F-L-Leu White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An N-protected leucine analog that acts as a selective modulator of peroxisome proliferator-activated receptor g (PPARg) (Ki = 15 µM). Displays weaker adipogenic activity than other nuclear receptor ligands. Two molecules of F-L-Leu interact with one PPARg molecule in a highly specific manner. Exhibits potent insulin sensitizing activity. Purity: ≥98% by HPLC. CAS 35661-60-0. Ref.: Rocchi, S., et al. 2001. Mol. Cell 8, 737. |