(±)-2-Fluoro-a-methyl[1,1′-biphenyl]-4-acetic Acid
U-27182 White solid. A mixture of S(+) and R(–) enantiomers. A cell-permeable, non-steroidal anti-inflammatory agent that acts as a potent inhibitor of cyclooxygenase (IC50 = 5 nM for LPS-induced COX in human peripheral blood cells). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Suppresses iNOS expression in RAW 264.7 macrophages. Reduces microglial activation and b-amyloid deposit in APP+PS1 transgenic mice. Purity: ≥98% by titration. RTECS DU8341000, CAS 5104-49-4. Merck Index: 14, 4199
Ref.: Jantzen, P.T., et al. 2002. J. Neurosci. 22, 2246. Hinz, R., et al. 2001. Pharmacol. Res. 18, 151. Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312. Range, S.P., et al. 2000. Eur. Respir. J. 15, 751. van Haeringen, N.J., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 353. Curnock, A.P., et al. 1997. J. Pharmacol. Exp. Ther. 282, 339. Reindeau, D., et al. 1997. Can. J. Physiol. Pharmacol. 75, 1088. Wechter, W.J., et al. 1997. Cancer Res. 57, 4316. Karmali, R.A., and Marsh, J. 1986. Prostaglandins Leukot. Med. 23, 11. Karmali, R.A., and Marsh, J. 1985. Prostaglandins Leukot. Med. 20, 283.
R: 25; S: 36/37/39-45 |
