7-O-[N-(4′-Fluoresceincarbonyl)-L-alanyl]TAXOL® Orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A fluorescent taxoid that reversibly interacts with the paclitaxel binding sites of microtubules with high affinity. It serves to image the microtubule cytoskeleton and induces cellular effects similar to Paclitaxel (Cat. No. 580555). May serve as a useful probe for developing screening assays for new drugs binding to the paclitaxel site. Purity: ≥95% by HPLC. Ref.: Abal, M., et al. 2001. Cell Motil. Cytoskeleton 49, 1. Diaz, J.F., et al. 2001. J. Biol. Chem. 275, 26265. Evangelio, J.A., et al. 1998. Cell Motil. Cytoskeleton 39, 73. Souto, A.A., et al. 1995. Angew. Chem. Int. Ed. Engl. 34, 2710.
R: 23/24/25-37/38-41-46-60; S: 22-26-36/37/39-45 |
