(±)-(3R′,5S′,6E)-7-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxy-6-heptenoate, sodium Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A synthetic HMG-CoA reductase inhibitor (IC50 = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic agent. Decreases the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Inhibits the formation of TBA-reactive substances in Fe(II)-supported peroxidation of liposomes (IC50 = 12 µM). Purity: ≥98% by HPLC. RTECS MJ9675050, CAS 93957-55-2. Merck Index: 14, 4218
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R: 61; S: 36/37/39-45 |
