(E,E)-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester, Na Pale yellow solid. HYGROSCOPIC. A cell-permeable prodrug ester form of farnesyltransferase (FTase) inhibitor II (Cat. No. 344152). Also inhibits Ras processing in cells (~100 µM), thereby preventing Ras-mediated transformation. Inhibits C15 and C20 protein prenylation in NIH-3T3 cells. Purity: ≥90% by HPLC. Ref.: Wang, D., et al. 1998. J. Biol. Chem. 273, 33027. Manne, V., et al. 1995. Drug Development Res. 34, 121. |
