FPRL1 Agonist, WKYMVm
H2N-WKYMV-D-M-CONH2 Lyophilized. Supplied as a trifluoroacetate salt. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue. Purity: ≥95% by HPLC. H-Trp-Lys-Tyr-Met-Val-D-Met-CONH2 Ref.: Bae, Y.S., et al. 2004. J. Immunol. 173, 607. Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841. Le, Y., et al. 1999. J. Immunol. 163, 6777. Seo, J.K., et al. 1997. J. Immunol. 158, 1895. Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170. |
