FPRL1 Antagonist, WRW4
H2N-WRWWWW-CONH2 White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Ab42 peptide-induced superoxide generation and prevents its internalization in human macrophages. Purity: ≥95% by HPLC. H-Trp-Arg-Trp-Trp-Trp-Trp-CONH2 Ref.: Bae, Y.S., et al. 2004. J. Immunol. 173, 607. | 
