SQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQ

White solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A peptide corresponding to amino acid residues 188 - 226 of FRAT1 (frequently rearranged in advanced T-cell lymphomas 1), a mammalian homolog of GSK-3 binding protein. Binds to the carboxyl-terminal lobe of GSK-3 (glycogen synthase kinase-3) and prevents the binding of “unprimed” substrates such as axin, b-catenin and tau. Exhibits little effect on GSK-3 catalyzed phosphorylation of “primed” (pre-phosphorylated) substrates such as glycogen synthase and eIF2B (elongation initiation factor 2B). Purity: ≥95% by HPLC.

H-Ser-Gln-Pro-Glu-Thr-Arg-Thr-Gly-Asp-Asp-Asp-Pro-His-Arg-Leu-Leu-Gln-Gln-Leu-Val-
Leu-Ser-Gly-Asn-Leu-Ile-Lys-Glu-Ala-Val-Arg-Arg-Leu-His-Ser-Arg-Arg-Leu-Gln-OH

Ref.: Bax, B., et al. 2001. Structure 9, 1143. Harwood, A.J. 2001. Cell 105, 821. Thomas, G.M., et al. 1999. FEBS Lett. 458, 247. Yost, C., et al. 1998. Cell 93, 1031.