8,13-Epoxy-7b-(N-methylpiperazino-g-butyryloxy)-1a,6b,9a-trihydroxy-labd-14-en-11-one, 2HCl
L-858051 White solid. HYGROSCOPIC. Chemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC50 = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells. Purity: ≥95% by HPLC. Ref.: Yang, C.M., et al. 1999. Cell Signal. 11, 697. Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880. Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255. Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.
R: 21; S: 36 |
