FST
Phosphotrienin Colorless solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC50 = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC50 = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner. Purity: ≥98% by HPLC. RTECS UQ0600000, CAS 87860-39-7. Ref.: Cheng, A., et al. 1998. Cancer Res. 58, 3611. Walsh, A.H., et al. 1997. FEBS Lett. 416, 230. Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063. |
