9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine White solid. PROTECT FROM MOISTURE. PACKAGED UNDER INERT GAS. A nucleoside analog structurally related to Acyclovir (Cat. No. 114798). Acts as a prodrug that is activated by phosphorylation. Has been used in the study of “suicide” gene therapy in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents. Purity: ≥98% by HPLC. RTECS MF8407000, CAS 82410-32-0. Merck Index: 14, 4363
Ref.: Aghi, M., et al. 2000. J. Gene Med. 2, 148. Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569. Cannon, J.S., et al. 1999. J. Virol. 73, 4786. Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669. Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781. Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151. Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.
R: 46-60-61; S: 36/37/39-45-53 |
