Neu5Aca2,3Galb1,4Glcb1,1 Ceramide, NH4 White solid. Contains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF. Purity: ≥98% by TLC. M.W. 1198.5 (based on stearoyl - 18:0). Ref.: Katoh, N. 1995. Life Sci. 56, 157. Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148. Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931. Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.
R: 36/37/38; S: 26-36 |
