1-(4′-Hydroxy-3′-methoxyphenyl)-5-hydroxy-3-decanone Pale yellow oil. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum (EC50 = 4 µM) and increases Ca2+ uptake. Purity: ≥95% by HPLC. RTECS HE0757000, CAS 23513-14-6. Ref.: Bode, A.M., et al. 2001. Cancer Res. 61, 850. Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227. Park, K.K.,et al. 1998. Cancer Lett. 129, 139. Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.
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