rhGDNF Lyophilized. PROTECT FROM MOISTURE. Recombinant, human glial derived neutotrophic factor expressed in E. coli. A heterogeneously glycosylated growth promoting factor that enhances neuronal survival of dopaminergic midbrain neurons. Activates receptor tyrosine kinase Ret and promotes kidney morphogenesis. Also an activator of MAP kinase. Its biological activity is destroyed by reduction of disulfide bonds. Biological activity: fully biologically active when compared to native GDNF by dose-dependent 3H-dopamine uptake assay. Purity: ≥97% by SDS-PAGE. Ref.: Vega, Q.C., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 10657. Worby, C.A., et al. 1996. J. Biol. Chem. 271, 23619. Lin, L.F., et al. 1994. J. Neurochem. 63, 758. Lev-Fen, H., et al. 1993. Science 260, 1130. |
