N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide Pale yellow solid. A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg. Purity: ≥98% by TLC. CAS 123653-11-2. Ref.: Ouellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247. Futaki, N., et al. 1994. Prostaglandins 47, 55. Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259. Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105. Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753. |
