TDZD-8
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione White to off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3b (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). Binds to the active site of GSK-3b. Purity: ≥ 95% by HPLC. Ref.: Guzman, M.L., et al. 2007. Blood 110, 4436. Barry, F.A., et al. 2003. FEBS Lett. 553, 173. Martinez, A., et al. 2002. J. Med. Chem. 45, 1292. |
