2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone Orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A thienyl a-chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3b (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3b and does not affect PKA activity even at concentrations as high as 100 µM. Purity: ≥95% by HPLC. Ref.: Conde, S., et al. 2003. J. Med. Chem. 46, 4631. |
