BIO-Acetoxime
(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime Dark purple solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3a/b (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 ≥ 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems. Purity: ≥95% by HPLC. Ref.: Knockaert, M., et al. 2004. Oncogene 23, 4400. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Meijer, L., et al. 2003. Chem. Biol. 10, 1255. |
