Neurogenesis Inducer, TWS119 Beige solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3b (IC50 = 30 nM). Binds to GSK-3b with high-affinity (Kd = 126 nM) and increases the level of b-catenin, a downstream substrate of GSK-3b in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM). Purity: ≥95% by HPLC. Ref.: Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632. | 
