Purple solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. The racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3a and GSK-3b, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3a GSK-3b, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3a GSK-3b, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage. Purity: ≥98% by HPLC. Ref.: Atilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.
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