Galardin
N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide Off-white solid. A potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8; and Ki = 200 pM for MMP-9). Prevents the release of TNF-a in vivo and in vitro and abrogates endotoxin-induced lethality in mice. Purity: ≥95% by HPLC. CAS 142880-36-2. Ref.: Solorzano, C.C., et al. 1997. Shock 7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315. Galardy, R.E., et al. 1994. Cancer Res. 54, 4715. Galardy, R.E. 1993. Drugs Future 18, 1109. Grobelny, D., et al. 1992. Biochemistry 31, 7152. |
