12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
Go 6976 Off-white solid. PROTECT FROM LIGHT. A cell-permeable inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC a-isozyme (IC50 = 2.3 nM) and PKCbI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC d-, e-, and z-isozymes even at micromolar levels. Reported to inhibit PKCµ at higher concentrations (IC50 = 20 nM). Purity: ≥95% by HPLC. CAS 136194-77-9. Ref.: Gschwendt, M., et al. 1996. FEBS Lett. 392, 77. Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536. Martiny-Baron, G.M., et al. 1993. J. Biol. Chem. 268, 9194. Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 4674.
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