2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide
Go 6983 Orange red solid. PROTECT FROM LIGHT. A potent, cell permeable inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCa and PKCb; 6 nM for PKCg; 10 nM for PKCd; and 60 nM for PKCz). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes. Purity: ≥95% by HPLC. Ref.: Wang, D., et al. 1998. J. Biol. Chem. 273, 33027. Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805. Gschwendt, M., et al. 1996. FEBS Lett. 392, 77. |
