Z-AE(OMe)VD(OMe)-FMK White solid. PROTECT FROM MOISTURE. A potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspase-6, -8, -9, and -10), although more effective towards caspases-6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. Purity: Single spot by TLC. Z-Ala-Glu(OMe)-Val-Asp(OMe)-CH2F* Ref.: Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. |
