DT-3
cGMP-dependent Protein Kinase Ia Inhibitor, Cell Permeable
cGPK Ia Inhibitor, Cell Permeable
Protein Kinase G Ia Inhibitor
RQIKIWFQNRRMKWKKLRKKKKKH Lyophilized. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A highly potent membrane-permeable Drosophila Antennapedia homeodomain fused-peptide that selectively inhibits protein kinase G Ia (Ki = 25 nM). Shown to efficiently translocate into arterial smooth muscle cells and inhibit NO-induced vasodilation (ED50 = 47 µM). Inhibits protein kinase A at much higher concentrations (Ki = 493 µM). The carrier peptide is also available under Cat. no. 287895. Purity: ≥95% by HPLC. H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH Ref.: Dostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772. | 
