Guanosine 3′,5′-cyclic Monophosphate, P-1-(2-Nitrophenyl)ethyl Ester Off-white to pale yellow solid. PROTECT FROM LIGHT. HYGROSCOPIC. Photolabile derivative of cGMP. Caged cGMP is a membrane-permeable, biologically inactive derivative that can be loaded into cells, then irradiated with pulses of light of 360 nm to cause concentration jumps of cGMP. Purity: ≥95% by TLC. Extinction coefficient (255 nm, MeOH): 16,900 M-1cm-1. Ref.: Crawford, J.H., et al. 1997. J. Neurophysiol. 77, 2573. Kaplan, J.H., and Somlyo, A.P. 1989. Trends Neurosci. 12, 54. |
